In theory, a wide puncher allows you to go down the middle. Tyson used the uppercut, for ex. The problem, of course, is who has the better defense. Fire and maneuver (or "stick and move") is what Ali used.
In the gif's case, a lot depends on when it occurred in the fight. Was the guy tired, and that's why he seemed to stand there and try to cover up? Or had he been hurt earlier? Let's agree that most people would be scared shit if Fedor was trying to hit them. That's not even counting what would happen after they got hit. (And, I mean me ).