https://news.usc.edu/101187/diet-that-m ... -symptoms/Diet that mimics fasting may also reduce multiple sclerosis symptoms
Previous studies indicated that similar diets could fight cancer and reduce the signs of agingEvidence is mounting that a diet mimicking the effects of fasting has health benefits beyond weight loss, with a new USC-led study indicating that it may reduce symptoms of multiple sclerosis.
Scientists discovered that the diet triggers a death-and-life process for cells that appears critical for the body’s repair.
“During the fasting-mimicking diet, cortisone is produced and that initiates a killing of autoimmune cells,” said Valter Longo, the study’s lead author and professor who directs the USC Longevity Institute at the Davis School of Gerontology. “This process also leads to the production of new healthy cells.”
The new study, published in the journal Cell Reports, included mice and human patients who have multiple sclerosis, a neurological disease that affects an estimated 350,000 Americans, according to the National Institute of Neurological Disorders and Stroke.Overseas trial
The researchers also checked the safety and potential efficacy of the diet on people who have multiple sclerosis through a pilot trial with 60 participants with the disease, lead by Markus Bock at Charité University Hospital in Berlin.
Eighteen patients were placed on the fasting-mimicking diet for a seven day cycle and then placed on a Mediterranean diet for six months. Also for six months, 12 participants were on a controlled diet, and 18 others were on a ketogenic diet (a high-fat diet).
Those who received a fasting-mimicking diet cycle followed by the Mediterranean diet and those on a ketogenic diet reported improvements in their quality of life and improvements in health, including physical and mental health.
The researchers noted that the study is limited because it did not test whether the Mediterranean diet alone would cause improvements, nor did it involve a functional MRI or immune function analysis.
Longo said the findings beg further investigation. Researchers should determine whether fasting-mimicking diet could help patients with other autoimmune diseases, and they should test the diet’s efficacy in larger clinical trials.
Similar fasting-mimicking diets have been tested and found safe in trials. Longo said he believes patients with autoimmune disorders who are out of viable options should consult their doctors about the possibility of trying a fasting-mimicking diet or enrolling in a clinical trial that tests the diet’s effect on autoimmune disorders.
Positive feedback
Longo said he has heard positive feedback from patients with disorders who tried the diet.
“We are optimistic,” Longo said. “What we don’t want is patients trying to do this at home without involvement of their specialist or without understanding that larger trials are necessary to confirm that the diet, as a treatment, is effective against multiple sclerosis or other autoimmunities.”
The study co-authors were In Young Choi, Sebastian Brandhorst, Jorge Suarez and Todd Morgan, and Min Wei, all of the USC Davis School; Patra Childress of the Keck School of Medicine at USC; Arko Ghosh of the USC Dornsife College of Letters, Arts and Sciences; Andreas Michalsen, Friedemann Paul and Markus Bock of Charité University Medicine Berlin; and Laura Piccio, Bryan Bollman and Anne Cross of Washington University School of Medicine.
The study was funded by the Fondazione Italiana Sclerosi Multipla (FISM; 2014/R/15); the U.S. Office of the Assistant Secretary of Defense for Health Affairs through the Multiple Sclerosis Research Program, (award number W81XWH-14-1-0156.). The mouse study was funded by National Institutes of Health/National Institute on Aging grant AG034906. The human study was funded by Meylin Projekt e.V. and Familie Ernst Wendt Stiftung Stadt Koeln. Paul’s work is funded by Deutsche Forschungsgemeinschaft (DFG Exc 257).
http://gero.usc.edu/faculty/longo/EducationBS, University of North Texas, 1992
Ph.D., UCLA, 1997
Postdoctoral training, USC, 2000
Research
Cell Biology and genetics
Regulation of aging and multiple stress resistance systems in yeast and mammals
Alzheimer’s Disease.
Cancer
Diabetes
Overview
Dr. Longo is the Edna Jones Professor in Gerontology and Professor in Biological Science. He is also the Director of the USC Longevity Institute. He is interested in understanding the fundamental mechanisms of aging in yeast, mice and humans by using genetics and biochemistry techniques. He is also interested in identifying the molecular pathways conserved from simple organisms to humans that can be modulated to protect against multiple stresses and treat or prevent cancer , Alzheimer’s Disease and other diseases of aging. The focus is on the signal transduction pathways that regulate resistance to oxidative damage in yeast and mice.
Courses Taught
Bisc 461 Seminar in Molecular and Computational Biology (2, max 4, FaSp) Topical seminar in molecular and computational biology. Junior, senior or graduate standing.
GERO 498 Nutrition, Genes, Longevity and Diseases (4, Sm) Examines the role of nutrition and genes and the impact each has on longevity and diseases, particularly diseases related to aging. Offered in Genoa, Italy.
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